Article
Characterization of mammary tumors from Brg1 heterozygous mice.
Oncogene - 17 Jan 2008
Bultman S J, Herschkowitz J I, Godfrey V, Gebuhr T C, Yaniv M, Perou C M, Magnuson T
Abstract excerpt
Mammalian SWI/SNF-related complexes have been implicated in cancer based on some of the subunits physically interacting with retinoblastoma (RB) and other proteins involved in carcinogenesis. Additionally, several subunits are mutated or not expressed in tumor-derived cell lines. Strong evidence for a role in tumorigenesis in vivo, however, has been limited to SNF5 mutations that result primarily in malignant...
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