Article
Nucks1 synergizes with Trp53 to promote radiation lymphomagenesis in mice.
Oncotarget - 20 Sept 2016
Yue Yangbo, Leung Stanley G, Liu Yueyong, Huang Yurong, Grundt Kirsten, Østvold Anne-Carine, Jen Kuang-Yu, Schild David, Mao Jian-Hua, Wiese Claudia
Abstract excerpt
NUCKS1 is a 27 kD vertebrate-specific protein, with a role in the DNA damage response. Here, we show that after 4 Gy total-body X-irradiation, Trp53+/- Nucks1+/- mice more rapidly developed tumors, particularly thymic lymphoma (TL), than Trp53+/- mice. TLs in both cohorts showed loss of heterozygosity (LOH) of the Trp53+ allele in essentially all cases. In contrast, LOH of the Nucks1+ allele was rare. Nucks1...
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