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Article

TAK1 lysine 158 is required for TGF-β-induced TRAF6-mediated Smad-independent IKK/NF-κB and JNK/AP-1 activation.

Cellular signalling - 1 Jan 2011

Mao Renfang, Fan Yihui, Mou Yonggao, Zhang Hong, Fu Songbin, Yang Jianhua

Abstract excerpt

Lys63-linked TAK1 polyubiquitination plays an essential role in the regulation of TAK1 activation. TRAF6-mediated Lys63-linked polyubiquitylation of TAK1 has been shown to be required for TGF-β-induced TAK1 activation. However, it remains unclear which lysine residue on TAK1 is TRAF6-mediated TAK1 polyubiquitination acceptor site in TGF-β signaling pathway. Here we report that lysine 158 on TAK1 is required for...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to p38 Mitogen-Activated Protein Kinases

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Source

Open in PubMed Open full text

Identifiers

PMID: 20837137
DOI: 10.1016/j.cellsig.2010.09.006
PMCID: PMC2956842

Genes

TRAF6
TAB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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