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Article

TAK1-dependent activation of AP-1 and c-Jun N-terminal kinase by receptor activator of NF-kappaB.

Journal of biochemistry and molecular biology - 31 Jul 2002

Lee Soo Woong, Han Sang-In, Kim Hong-Hee, Lee Zang Hee

Abstract excerpt

The receptor activator of nuclear factor kappa B (RANK) is a member of the tumor necrosis factor (TNF) receptor superfamily. It plays a critical role in osteoclast differentiation, lymph node organogenesis, and mammary gland development. The stimulation of RANK causes the activation of transcription factors NF-kappaB and activator protein 1 (AP1), and the mitogen activated protein kinase (MAPK) c-Jun N-terminal...

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Source

Identifiers

PMID: 12296995
DOI: 10.5483/bmbrep.2002.35.4.371

Genes

TNF
TRAF6
TRAF2
TRAF5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

TAK1-dependent activation of AP-1 and c-Jun N-terminal kinase by receptor activator of NF-kappaB.PMID 12296995Read ↗

TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo.Semantic proximity Read ↗

Phosphorylation-dependent activation of TAK1 mitogen-activated protein kinase kinase kinase by TAB1.Semantic proximity Read ↗

Activation of c-Jun N-terminal kinase and activator protein 1 by receptor activator of nuclear factor kappaB.Semantic proximity Read ↗

Characterization of the intracellular domain of receptor activator of NF-kappaB (RANK). Interaction with tumor necrosis factor receptor-associated factors and activation of NF-kappab and c-Jun N-terminal kinase.Semantic proximity Read ↗

TAK1 regulates NF-ΚB and AP-1 activation in airway epithelial cells following RSV infection.Semantic proximity Read ↗

The kinase activity of IL-1 receptor-associated kinase 4 is required for interleukin-1 receptor/toll-like receptor-induced TAK1-dependent NFkappaB activation.Semantic proximity Read ↗

TRAF4 functions as an intermediate of GITR-induced NF-kappaB activation.Semantic proximity Read ↗

Selective disruption of Traf1/cIAP2 interaction attenuates inflammatory responses and limits sepsis and rheumatoid arthritisSemantic proximity Read ↗

MAPKK-independent activation of p38alpha mediated by TAB1-dependent autophosphorylation of p38alpha.Semantic proximity Read ↗

Osteopetrosis in TAK1-deficient mice owing to defective NF-κB and NOTCH signaling.Semantic proximity Read ↗

The TAK1–TRAF6 signalling pathwaySemantic proximity Read ↗

NF-kappaB activator Act1 associates with IL-1/Toll pathway adaptor molecule TRAF6.Semantic proximity Read ↗

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