Article
CYP46 T/C polymorphism is not associated with Alzheimer's dementia in a population from Hungary.
Neurochemical research - 1 Aug 2005
Juhász Anna, Rimanóczy Agnes, Boda Krisztina, Vincze Gábor, Szlávik Gyozo, Zana Marianna, Bjelik Annamária, Pákáski Magdolna, Bódi Nikoletta, Palotás András, Janka Zoltán, Kálmán János
Abstract excerpt
Multiple genetic and environmental factors regulate the susceptibility to Alzheimer's disease (AD). Recently, several independent studies have reported that a locus on chromosome 14q32.1, where a gene encoding a cholesterol degrading enzyme of the brain, called 24-hydroxylase (CYP46A1) is located, has been linked with AD. The single nucleotide polymorphism (T/C) in intron 2 of CYP46 gene has been found to confer...
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