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Article

Intronic regulation of <i>matrix metalloproteinase-2</i> revealed by <i>in vivo</i> transcriptional analysis in ischemia

28 Oct 2005

Abstract excerpt

Matrix metalloproteinase-2 (MMP-2) plays an essential role in angiogenesis and arteriogenesis, two processes critical to restoration of tissue perfusion after ischemia. MMP-2 expression is increased in tissue ischemia, but the responsible mechanisms remain unknown. We studied the transcriptional activation of the MMP-2 gene in a model of hindlimb ischemia by using various MMP-2-lacZ reporter mice and chromatin...

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PMID: 16258061
DOI: 10.1073/pnas.0508085102

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