Regulation of Matrix Metalloproteinase (Matrixin) Genes in Blood Vessels: A Multi-Step Recruitment Model for Pathological Remodelling

Abstract excerpt

Matrix metalloproteinases (MMPs; matrixins) are a family of structurally related enzymes that collectively promote turnover of all components of the extracellular matrix. Matrix turnover is required for vascular repair, but, if excessive, leads to pathologies that include aneurysm formation and atherosclerotic plaque instability. We review the positive and negative regulation of metalloproteinase gene induction....

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