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Article

MT1-MMP-dependent neovessel formation within the confines of the three-dimensional extracellular matrix.

The Journal of cell biology - 22 Nov 2004

Chun Tae-Hwa, Sabeh Farideh, Ota Ichiro, Murphy Hedwig, McDonagh Kevin T, Holmbeck Kenn, Birkedal-Hansen Henning, Allen Edward D, Weiss Stephen J

Abstract excerpt

During angiogenesis, endothelial cells initiate a tissue-invasive program within an interstitial matrix comprised largely of type I collagen. Extracellular matrix-degradative enzymes, including the matrix metalloproteinases (MMPs) MMP-2 and MMP-9, are thought to play key roles in angiogenesis by binding to docking sites on the cell surface after activation by plasmin- and/or membrane-type (MT) 1-MMP-dependent...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 15545316
DOI: 10.1083/jcb.200405001
PMCID: PMC2172577

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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