Article
Tissue-specific enhancer-promoter interactions regulate high level constitutive expression of matrix metalloproteinase 2 by glomerular mesangial cells.
The Journal of biological chemistry - 11 Aug 1995
Harendza S, Pollock A S, Mertens P R, Lovett D H
Abstract excerpt
The 72-kDa gelatinase A (MMP-2) is a central mediator of the response of the intrinsic glomerular mesangial cell to inflammatory stimuli and is regulated in a unique, cell-specific manner. We isolated a 6-kilobase pair genomic fragment of the rat MMP-2 gene and sequenced and characterized 1686-ba...
Topics
- Animals
- Base Sequence
- Cells, Cultured
- Enhancer Elements, Genetic
- Gelatinases
- Glomerular Mesangium
- Humans
- Matrix Metalloproteinase 2
- Metalloendopeptidases
- Molecular Sequence Data
- Mutation
- Organ Specificity
- Promoter Regions, Genetic
- Rats
- Transcription, Genetic