Article

Inhibition of CDK8 rescues impaired ischemic fracture healing

2025-05-16

Abstract excerpt

<title>Abstract</title> <p> Annually, 10% of 15 million bone fractures in the US fail to heal, and fractures with compromised blood flow, i.e. ischemia, are five times more likely to become nonunions. While ischemia is known to impair healing, the cellular and molecular mechanisms underlying this deficiency are unclear. Wild-type mice with surgically-induced ischemia underwent tibia fractures, and single-cell RN...

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Literature Corpus work: 21e93643-96f8-5fbe-b754-0a48b8fe127c
DOI: 10.21203/rs.3.rs-6458483/v1

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