Article
Sirtuin 1 (SIRT1) sequence variation is not associated with exceptional human longevity.
Experimental gerontology - 1 Jan 2006
Flachsbart Friederike, Croucher Peter J P, Nikolaus Susanna, Hampe Jochen, Cordes Christina, Schreiber Stefan, Nebel Almut
Abstract excerpt
The SIR2/Sirt1 gene has been demonstrated as regulating lifespan in many model organisms, including yeast, Caenorhabditis elegans and rodents. These findings render the human homologue, SIRT1, a very plausible candidate as a modifier of human life expectancy. We therefore sought to investigate whether common allelic variation in the SIRT1 gene was associated with human longevity. Five single nucleotide...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.