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Article

SIRT1 polymorphism, long-term survival and glucose tolerance in the general population.

PloS one - 1 Jan 2013

Figarska Sylwia M, Vonk Judith M, Boezen H Marike

Abstract excerpt

Mutations that increase activity of Sir2 (silent information regulator 2) are associated with extended lifespan of yeast, fruit flies and worms. SIRT1, the human homolog of Sir2, that controls numerous physiological processes including the glucose metabolism, is considered a candidate gene for predicting variation in human lifespan. Whereas the role of Sir2 has been extensively investigated in model organisms,...

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Source

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Identifiers

PMID: 23505545
DOI: 10.1371/journal.pone.0058636
PMCID: PMC3591365

Genes

SIRT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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