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Article

A remarkable age-related increase in SIRT1 protein expression against oxidative stress in elderly: SIRT1 gene variants and longevity in human.

PloS one - 1 Jan 2015

Kilic Ulkan, Gok Ozlem, Erenberk Ufuk, Dundaroz Mehmet Rusen, Torun Emel, Kucukardali Yasar, Elibol-Can Birsen, Uysal Omer, Dundar Tolga

Abstract excerpt

Aging is defined as the accumulation of progressive organ dysfunction. Controlling the rate of aging by clarifying the complex pathways has a significant clinical importance. Nowadays, sirtuins have become famous molecules for slowing aging and decreasing age-related disorders. In the present study, we analyzed the SIRT1 gene polymorphisms (rs7895833 A>G, rs7069102 C>G and rs2273773 C>T) and its relation with...

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Share to Aged, 80 and over
Share to Aryldialkylphosphatase
Share to Child, Preschool
Share to Gene Expression Regulation, Enzymologic
Share to Longevity
Share to Nitric Oxide Synthase Type III
Share to Oxidative Stress
Share to Sirtuin 1

Source

Open in PubMed Open full text

Identifiers

PMID: 25785999
DOI: 10.1371/journal.pone.0117954
PMCID: PMC4365019

Genes

SIRT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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