Article
SIRT1 gene, age-related diseases, and mortality: the Leiden 85-plus study.
The journals of gerontology. Series A, Biological sciences and medical sciences - 1 Sept 2007
Kuningas Maris, Putters Mariëlle, Westendorp Rudi G J, Slagboom P Eline, van Heemst Diana
Abstract excerpt
The (Silent Information Regulator 2) Sir2 gene has been shown to regulate the life span of several model organisms. In mammals, the evolutionarily conserved homologue (Sirtuin 1) SIRT1 regulates neuroprotection, metabolism, and cell survival in response to stress. Based on these data, we hypothesized that SIRT1 might influence the prevalence of age-related diseases and modify the life span of humans. In order to...
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