Article
Common variants in SIRT1 and human longevity in a Chinese population.
BMC medical genetics - 18 Apr 2016
Lin Rong, Yan Dongjing, Zhang Yunxia, Liao Xiaoping, Gong Gu, Hu Junjie, Fu Yunxin, Cai Wangwei
Abstract excerpt
BACKGROUND: The silent information regulator SIR2/SIRT1gene has been demonstrated as regulating lifespan in many model organisms, including yeast, worms, fruit flies and rodents. SIRT1, the human homolog of SIR2, is considered a candidate gene as a modifier of human life expectancy. METHODS: In the current study we included 616 long-lived individuals and 846 matched younger controls to investigate associations...
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