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Article

SIRT6 polymorphism rs117385980 is associated with longevity and healthy aging in Finnish men.

BMC medical genetics - 11 Apr 2017

Hirvonen Katariina, Laivuori Hannele, Lahti Jari, Strandberg Timo, Eriksson Johan G, Hackman Peter

Abstract excerpt

BACKGROUND: Sirtuin-6 (SIRT6) is involved in various crucial cellular pathways, being a key regulator of telomere structure, DNA repair, metabolism, transcriptional control and the NF-kappa B pathway. Sirt6 knock-out mice have been reported to develop typical features of aging and senescence at the age of 2-3 weeks and die within 4 weeks. The aim of this study was to investigate whether sequence variations of...

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Identifiers

PMID: 28399814
DOI: 10.1186/s12881-017-0401-z
PMCID: PMC5387321

Genes

SIRT6
MAF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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