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Article

SIRT6 minor allele genotype is associated with >5-year decrease in lifespan in an aged cohort.

PloS one - 1 Jan 2014

TenNapel Mindi J, Lynch Charles F, Burns Trudy L, Wallace Robert, Smith Brian J, Button Anna, Domann Frederick E

Abstract excerpt

Aging is a natural process involving complex interplay between environment, metabolism, and genes. Sirtuin genes and their downstream targets have been associated with lifespan in numerous organisms from nematodes to humans. Several target proteins of the sirtuin genes are key sensors and/or effectors of oxidative stress pathways including FOXO3, SOD3, and AKT1. To examine the relationship between single...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 25541994
DOI: 10.1371/journal.pone.0115616
PMCID: PMC4277407

Genes

SIRT6
AKT1
FOXO3
SIRT3
SIRT5
SOD3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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