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Article

Linking SIRT1 Variants to Metabolic and Cardiovascular Phenotypes: Insights from Population Genetics and In Silico Structural Analysis.

Cell biochemistry and biophysics - 1 Mar 2026

Grebenshchikov Eugene S, Pravednikova Anna E, Bezsonov Evgeny E, Kudryavtsev Denis S, Larina Svetlana N, Shidlovskii Yulii V

Abstract excerpt

The sirtuin (SIRT) family, particularly SIRT1, plays a pivotal role in cell metabolism, inflammation, and aging through its NAD+-dependent deacetylase activity. SIRT1 modulates signaling pathways by targeting numerous regulatory proteins and transcription factors (TFs). Among these is the forkhead TF FOXO1, which plays a key role in regulating genes associated with inflammation (TNF-α), oxidative stress, and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Polymorphism, Single Nucleotide

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Source

Identifiers

PMID: 40991201
DOI: 10.1007/s12013-025-01903-2

Genes

SIRT1
FOXO1
PPARG
TF
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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