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Article

SELPLG and SELP single-nucleotide polymorphisms in multiple sclerosis.

Neuroscience letters - 13 Feb 2006

Fenoglio Chiara, Galimberti Daniela, Ban Maria, Maranian Mel, Scalabrini Diego, Venturelli Eliana, Piccio Laura, De Riz Milena, Yeo Tai Wai, Goris An, Gray Julia, Bresolin Nereo, Scarpini Elio, Compston Alastair, Sawcer Stephen

Abstract excerpt

P-Selectin (SELP) and P-selectin glycoprotein ligand-1 (SELPLG) constitute a receptor/ligand complex involved in the recruitment of activated lymphocytes, a critical event in the pathogenesis of multiple sclerosis (MS). In order to determine whether genetic variation in these pivotal molecules influences susceptibility to MS, we genotyped 214 Italian patients compared with 220 Italian controls for three...

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Source

Identifiers

PMID: 16257118
DOI: 10.1016/j.neulet.2005.10.014

Genes

SELP
SELPLG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

SELPLG and SELP single-nucleotide polymorphisms in multiple sclerosis.PMID 16257118Read ↗

No association between E- and L-selectin genes and SLE: soluble L-selectin levels do correlate with genotype and a subset in SLE.Semantic proximity Read ↗

The Ser290Asn and Thr715Pro Polymorphisms of the SELP Gene Are Associated with A Lower Risk of Developing Acute Coronary Syndrome and Low Soluble P-Selectin Levels in A Mexican Population ‡.Semantic proximity Read ↗

Association of SELP Polymorphisms with Soluble P-Selectin Levels and Vascular Risk in Patients with Type 2 Diabetes Mellitus: A Case-Control Study.Semantic proximity Read ↗

Bioinformatics Analyzes of Selectins Polymorphisms Reveal New Potential Cancer BiomarkersSemantic proximity Read ↗

Putative functional non-coding polymorphisms in SELP significantly modulate sP-selectin levels, arterial stiffness and type 2 diabetes mellitus susceptibility.Semantic proximity Read ↗

Detection of a large deletion in the P-selectin (SELP) gene.Semantic proximity Read ↗

Clinical and genetic correlates of soluble P-selectin in the community.Semantic proximity Read ↗

P-selectin glycoprotein ligand-1 variable number of tandem repeats (VNTR) polymorphism in patients with multiple sclerosis.Semantic proximity Read ↗

An evolutionary history of the selectin gene cluster in humans.Semantic proximity Read ↗

Cellular adhesion gene SELP is associated with rheumatoid arthritis and displays differential allelic expression.Semantic proximity Read ↗

Variation in the upstream region of P-Selectin (SELP) is a risk factor for SLE.Semantic proximity Read ↗

The P-selectin gene is highly polymorphic: reduced frequency of the Pro715 allele carriers in patients with myocardial infarction.Semantic proximity Read ↗

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