Article
No association between E- and L-selectin genes and SLE: soluble L-selectin levels do correlate with genotype and a subset in SLE.
Genes and immunity - 1 Aug 2005
Russell A I, Cunninghame Graham D S, Chadha S, Roberton C, Fernandez-Hart T, Griffiths B, D'Cruz D, Nitsch D, Whittaker J C, Vyse T J
Abstract excerpt
Altered function of selectin glycoprotein adhesion molecules may modulate severity and organ-specific manifestations of autoimmune and inflammatory disease via changes in leukocyte trafficking. Serum concentrations of selectin molecules have been suggested as useful biomarkers in systemic lupus erythematosus (SLE). We identified increased levels of soluble L-selectin (sL-selectin), but not soluble E-selectin...
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