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Article

An evolutionary history of the selectin gene cluster in humans.

Heredity - 1 Aug 2012

Fumagalli M, Fracassetti M, Cagliani R, Forni D, Pozzoli U, Comi G P, Marini F, Bresolin N, Clerici M, Sironi M

Abstract excerpt

Molecules involved in leukocyte trafficking have a central role in the development of inflammatory and immune responses. We performed F(ST) analysis of the selectin cluster, as well as of SELPLG, ICAM1 and VCAM1. Peaks of significantly high population genetic differentiation were restricted to two regions in SELP and one in SELPLG. Resequencing data indicated that the region covering SELP exons 11-13 displays...

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Source

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Identifiers

PMID: 22549518
DOI: 10.1038/hdy.2012.20
PMCID: PMC3400748

Genes

SELP
SELPLG
ICAM1
VCAM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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