Article
Protein kinase C-associated kinase is not required for the development of peripheral B lymphocyte populations.
Molecular immunology - 1 Apr 2006
Moran Stewart T, Cariappa Annaiah, Liu Haoyuan, Boboila Cristian, Shi Hai Ning, Holland Pamela M, Peschon Jacques J, Pillai Shiv
Abstract excerpt
Protein kinase C-associated kinase (PKK; DIK/RIP4) is an ankyrin-repeat containing serine/threonine receptor-interacting protein (RIP)-family kinase that can activate NFkappaB, and is required for keratinocyte development. In earlier studies, the expression of a catalytically inactive mutant of PKK in the B cell lineage resulted in a marked decrease in peripheral B cells in the spleen and a severe reduction of...
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