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Delineating Human B Cell Precursor Development With Genetically Identified PID Cases as a Model

26 Nov 2019

Abstract excerpt

B-cell precursors (BCP) arise from hematopoietic stem cells in bone marrow (BM). Identification and characterization of the different BCP subsets has contributed to the understanding of normal B-cell development. BCP first rearrange their immunoglobulin (Ig) heavy chain (IGH) genes to form the pre-B-cell receptor (pre-BCR) complex together with surrogate light chains. Appropriate signaling via this pre-BCR...

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PMID: 31849931
DOI: 10.3389/fimmu.2019.02680

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