Article
Analysis of mutations in the Gs protein alpha subunit gene in human leukaemia.
Leukemia research - 1 Jan 1992
Baker B W, Norton J D
Abstract excerpt
Mutations at codons 201 and 227 that cause oncogenic activation of the gene encoding the Gs alpha subunit protein occur in a subset of human solid tumours. To determine whether such oncogenic mutations occur in leukaemia we have analysed DNA from leukaemic cells from 59 patients representing a spectrum of acute and chronic leukaemia types by direct nucleotide sequence analysis of polymerase chain reaction (PCR)...
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