Article
No evidence for oncogenic mutations in guanine nucleotide-binding proteins of human adrenocortical neoplasms.
The Journal of clinical endocrinology and metabolism - 1 Nov 1993
Reincke M, Karl M, Travis W, Chrousos G P
Abstract excerpt
G-Proteins are membrane-bound heterotrimeric polypeptides that couple receptor signals to second messenger systems such as cAMP. Recently, point mutations at 2 codons of the highly preserved alpha-chain of Gs, the adenyl cyclase-stimulating G-protein, were found in GH-secreting pituitary tumors....
Topics
- Adolescent
- Adrenal Cortex Neoplasms
- Adult
- Aged
- Base Sequence
- Codon
- DNA
- Female
- GTP-Binding Proteins
- Humans
- Male
- Middle Aged
- Molecular Probes
- Molecular Sequence Data
- Mutation
- Oncogenes
- Polymerase Chain Reaction