Article
No evidence for oncogenic mutations in guanine nucleotide-binding proteins of human adrenocortical neoplasms.
The Journal of clinical endocrinology and metabolism - 1 Nov 1993
Reincke M, Karl M, Travis W, Chrousos G P
Abstract excerpt
G-Proteins are membrane-bound heterotrimeric polypeptides that couple receptor signals to second messenger systems such as cAMP. Recently, point mutations at 2 codons of the highly preserved alpha-chain of Gs, the adenyl cyclase-stimulating G-protein, were found in GH-secreting pituitary tumors. These mutations resulted in constitutively activated Gs alpha and high intracellular cAMP levels. In addition, point...
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