Article
Analysis of the Gs alpha gene in growth hormone-secreting pituitary adenomas by the polymerase chain reaction-direct sequencing method using paraffin-embedded tissues.
Acta endocrinologica - 1 Oct 1993
Hosoi E, Yokogoshi Y, Hosoi E, Horie H, Sano T, Yamada S, Saito S
Abstract excerpt
We investigated the prevalence of Gs alpha gene mutations in growth hormone (GH) secreting pituitary adenomas from Japanese patients with acromegaly. Forty-five GH-secreting adenomas were examined for the presence of point mutations in codons 201 or 227 of the Gs alpha gene using the polymerase c...
Topics
- Adenoma
- Adult
- Aged
- Base Sequence
- Female
- Genes
- Growth Hormone
- Humans
- Male
- Middle Aged
- Molecular Probes
- Molecular Sequence Data
- Mutation
- Paraffin Embedding
- Pituitary Neoplasms
- Polymerase Chain Reaction