Identification of G protein alpha subunit mutations in human growth hormone (GH)- and GH/prolactin-secreting pituitary tumors by single-strand conformation polymorphism (SSCP) analysis.

doi:10.1016/0303-7207(92)90240-7

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Article

Identification of G protein alpha subunit mutations in human growth hormone (GH)- and GH/prolactin-secreting pituitary tumors by single-strand conformation polymorphism (SSCP) analysis.

Molecular and cellular endocrinology - 1 Sept 1992

Drews R T, Gravel R A, Collu R

Abstract excerpt

We have applied the polymerase chain reaction (PCR) and single-strand conformation polymorphism analysis (SSCP) to detect activating mutations in the Gs alpha subunit gene, amplifying genomic DNA extracted from growth hormone (GH)- and GH/prolactin (PRL)-secreting human pituitary tumors. Of 15 tumors tested six contained mutations in the analyzed regions of the Gs alpha. SSCP analysis revealed band shift in exon...

Topics

Adenoma
Base Sequence
Codon
DNA Mutational Analysis
DNA, Neoplasm
DNA, Single-Stranded
Enzyme Activation
Exons
GTP Phosphohydrolases
GTP-Binding Proteins
Growth Hormone

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Molecular Sequence Data

Mutation

Neoplasm Proteins

Nucleic Acid Conformation

Pituitary Neoplasms

Polymerase Chain Reaction

Source

Open in PubMed

Identifiers

PMID: 1446784
DOI: 10.1016/0303-7207(92)90240-7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1446784-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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