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Article

GTPase-inhibiting mutations activate the alpha-chain of Gs in human tumours.

Biochemical Society symposium - 1 Jan 1990

Vallar L

Abstract excerpt

Several trophic hormones transmit their signals by coupling to G-proteins. A subset of human growth hormone (GH)-secreting pituitary tumours, characterized by elevated GH secretion, cyclic AMP levels, and adenylyl cyclase activity, carries mutations in the gene that encodes the alpha-chain of Gs. By substitution of a single amino acid (Arg-201 or Gln-227), these mutations inhibit the intrinsic GTPase activity of...

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PMID: 2124121

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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