Article
A C-terminal FMS mutation in a patient with B-cell malignancy.
Leukemia - 1 Jan 1995
Baker A H, Ball S, McGlynn H, Whittaker J A, Burnett A K, Padua R A
Abstract excerpt
The FMS proto-oncogene encodes a polypeptide growth factor receptor expressed on the cell surface of monocytes and B lymphocytes within the haematological system. Mutations of the FMS gene at codons 301 and 969 have been detected in a number of haematological disorders. Mutations at these codons are thought to be important in the pathogenesis of leukaemia in cells expressing a mutant receptor. Following our...
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