Absence of G(s)alpha gene mutations in childhood thyroid tumors after Chernobyl in contrast to sporadic adult thyroid neoplasia.

Article

Absence of G(s)alpha gene mutations in childhood thyroid tumors after Chernobyl in contrast to sporadic adult thyroid neoplasia.

Cancer research - 15 Jun 1997

Waldmann V, Rabes H M

Abstract excerpt

Heterotrimeric G proteins participate in the signal transduction cascade. Adult thyroid tumors have been shown to harbor specific point mutations in codons 201 and 227 of the G(s)alpha subunit of the adenylate cyclase stimulator. This protein affects the GDP/GTP turnover and finally results in an...

Topics

Carcinoma, Papillary
Child
GTP-Binding Protein alpha Subunits, Gs
Humans
Mutation
Polymerase Chain Reaction
Radioactive Hazard Release
Republic of Belarus
Thyroid Neoplasms
Ukraine

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