A new constitutively activating mutation of the Gs protein alpha subunit-gsp oncogene is found in human pituitary tumours.

Article

A new constitutively activating mutation of the Gs protein alpha subunit-gsp oncogene is found in human pituitary tumours.

Oncogene - 1 Jul 1990

Clementi E, Malgaretti N, Meldolesi J, Taramelli R

Abstract excerpt

A new 227 Gln----Lys oncogenic mutation of the Gs alpha subunit (the GTP-binding protein that stimulates adenylyl cyclase) has been found in three out of eight human growth hormone-secreting pituitary tumours of the group 2, characterized by high cAMP and constitutively activated adenylyl cyclase...

Topics

Adenylyl Cyclases
Base Sequence
Codon
GTP-Binding Proteins
Humans
Macromolecular Substances
Molecular Sequence Data
Mutation
Oligonucleotides
Pituitary Neoplasms
Polymerase Chain Reaction

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