Distribution of Gs-alpha activating mutations in human thyroid tumors measured by subcloning.

doi:10.1007/BF01187156

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Article

Distribution of Gs-alpha activating mutations in human thyroid tumors measured by subcloning.

Journal of cancer research and clinical oncology - 1 Jan 1996

Gorelov V N, Gyenes M, Neser F, Röher H D, Goretzki P E

Abstract excerpt

In the search for the prevalence and distribution pattern of Gs-alpha gene mutations in differentiated thyroid tumors we examined 66 tumor tissue samples for the presence of mutations at "hot-spot" codons 201 and 227 using methods based on the polymerase chain reaction, subcloning and sequencing....

Topics

Adult
Aged
Base Sequence
Cloning, Molecular
Codon
DNA
Escherichia coli
Female
GTP-Binding Proteins
Humans
Male
Middle Aged
Molecular Sequence Data
Mutation
Thyroid Neoplasms

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