Article
Analysis of mutations in the GM-CSF receptor alpha coding sequence in patients with acute myeloid leukaemia and haematologically normal individuals by RT-PCR-SSCP.
Leukemia - 1 Sept 1994
Wagner H M, Gale R E, Freeburn R W, Devereux S, Linch D C
Abstract excerpt
Mutations of signal transducing molecules such as Ras have been shown to confer a growth advantage in leukaemic blasts and contribute to the pathogenesis of the disease. Alterations of signal transducing molecules other than Ras may play a role in leukaemogenesis. Knowledge of such mutations could also further our understanding of the normal signalling processes. We have therefore studied the coding sequence of...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.