Article
Analysis of mutations in the GM-CSF receptor alpha coding sequence in patients with acute myeloid leukaemia and haematologically normal individuals by RT-PCR-SSCP.
Leukemia - 1 Sept 1994
Wagner H M, Gale R E, Freeburn R W, Devereux S, Linch D C
Abstract excerpt
Mutations of signal transducing molecules such as Ras have been shown to confer a growth advantage in leukaemic blasts and contribute to the pathogenesis of the disease. Alterations of signal transducing molecules other than Ras may play a role in leukaemogenesis. Knowledge of such mutations coul...
Topics
- Adolescent
- Adult
- Aged
- Base Sequence
- DNA, Single-Stranded
- Female
- Genetic Code
- Humans
- Leukemia, Myeloid, Acute
- Male
- Middle Aged
- Molecular Sequence Data
- Mutation
- Nucleic Acid Conformation
- Polymerase Chain Reaction
- Polymorphism, Genetic
- RNA
- RNA, Neoplasm