Article
Predicting RNA folding thermodynamics with a reduced chain representation model.
RNA (New York, N.Y.) - 1 Dec 2005
Cao Song, Chen Shi-Jie
Abstract excerpt
Based on the virtual bond representation for the nucleotide backbone, we develop a reduced conformational model for RNA. We use the experimentally measured atomic coordinates to model the helices and use the self-avoiding walks in a diamond lattice to model the loop conformations. The atomic coordinates of the helices and the lattice representation for the loops are matched at the loop-helix junction, where...
Topics
- Animals
- Models, Molecular
- Models, Statistical
- Mutation
- Nucleic Acid Conformation
- RNA
- RNA Stability
- RNA, Catalytic
- RNA, Protozoan
- Temperature
- Tetrahymena
- Thermodynamics