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Article

Exploring the energetic and conformational properties of the sequence space connecting naturally occurring RNA tetraloop receptor motifs.

RNA (New York, N.Y.) - 18 Nov 2024

Shin John H, Cuevas Lena M, Roy Rohit, Bonilla Steve L, Al-Hashimi Hashim, Greenleaf William J, Herschlag Daniel

Abstract excerpt

Folded RNAs contain tertiary contact motifs whose structures and energetics are conserved across different RNAs. The transferable properties of RNA motifs simplify the RNA folding problem, but measuring energetic and conformational properties of many motifs remains a challenge. Here, we use a high-throughput thermodynamic approach to investigate how sequence changes alter the binding properties of naturally...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 39362695
DOI: 10.1261/rna.080039.124
PMCID: PMC11571812

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