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Article

Tissue kallikrein-deficient mice display a defect in renal tubular calcium absorption.

Journal of the American Society of Nephrology : JASN - 1 Dec 2005

Picard Nicolas, Van Abel Monique, Campone Christelle, Seiler Michelle, Bloch-Faure May, Hoenderop Joost G J, Loffing Johannes, Meneton Pierre, Bindels René J M, Paillard Michel, Alhenc-Gelas François, Houillier Pascal

Abstract excerpt

Renal tubular calcium (RTCa) transport is one of the main factors that determine serum Ca concentration and urinary Ca excretion. The distal convoluted and connecting tubules reabsorb a significant fraction (10%) of filtered Ca. These tubule segments also synthesize in large abundance tissue kallikrein (TK), a major kinin-forming enzyme. Tested was the hypothesis that TK and kinins are involved in controlling...

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Identifiers

PMID: 16251243
DOI: 10.1681/ASN.2004110923

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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