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Article

A direct synthesis of pyrrolocytosine from 5-iodocytosine.

Nucleosides, nucleotides & nucleic acids - 1 Jan 2005

Hudson R H E, Dambenieks A K, Viirre R D

Abstract excerpt

We have employed a tandem Sonogashira/annulation reaction between 5-iodocytosine derivatives and terminal alkynes to yield the fluorescent bicyclic nucleobase pyrrolcytosine. Pyrrolocytosine bearing substituents only on the pyrrole ring are conveniently synthesized from 5-iodocytosine. Water soluble pyrrolocytosines are being investigated as reporter groups in SNP analysis.

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Identifiers

PMID: 16247992
DOI: 10.1081/ncn-200061905

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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