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Article

Pyridone Luciferins and Mutant Luciferases for Bioluminescence Imaging.

Chembiochem : a European journal of chemical biology - 2 Mar 2018

Zhang Brendan S, Jones Krysten A, McCutcheon David C, Prescher Jennifer A

Abstract excerpt

New applications for bioluminescence imaging require an expanded set of luciferase enzymes and luciferin substrates. Here, we report two novel luciferins for use in vitro and in cells. These molecules comprise regioisomeric pyridone cores that can be accessed from a common synthetic route. The analogues exhibited unique emission spectra with firefly luciferase, although photon intensities remained weak. Enhanced...

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Identifiers

PMID: 29384255
DOI: 10.1002/cbic.201700542
PMCID: PMC6163054

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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