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Article

First Contact: 7-Phenyl-2-Aminoquinolines, Potent and Selective Neuronal Nitric Oxide Synthase Inhibitors That Target an Isoform-Specific Aspartate.

Journal of medicinal chemistry - 14 May 2020

Cinelli Maris A, Reidl Cory T, Li Huiying, Chreifi Georges, Poulos Thomas L, Silverman Richard B

Abstract excerpt

Inhibition of neuronal nitric oxide synthase (nNOS), an enzyme implicated in neurodegenerative disorders, is an attractive strategy for treating or preventing these diseases. We previously developed several classes of 2-aminoquinoline-based nNOS inhibitors, but these compounds had drawbacks including off-target promiscuity, low activity against human nNOS, and only modest selectivity for nNOS over related...

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PMID: 32302123
DOI: 10.1021/acs.jmedchem.9b01573
PMCID: PMC7429991

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