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Article

Phenyl-imidazolo-cytidine analogues: structure-photophysical activity relationship and ability to detect single DNA mismatch.

The Journal of organic chemistry - 1 Aug 2014

Kovaliov Marina, Weitman Michal, Major Dan Thomas, Fischer Bilha

Abstract excerpt

To expand the arsenal of fluorescent cytidine analogues for the detection of genetic material, we synthesized para-substituted phenyl-imidazolo-cytidine ((Ph)ImC) analogues 5a-g and established a relationship between their structure and fluorescence properties. These analogues were more emissive than cytidine (λem 398-420 nm, Φ 0.009-0.687), and excellent correlation was found between Φ of 5a-g and σp(-) of the...

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PMID: 24992467
DOI: 10.1021/jo5011944

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