Article
JNK-interacting leucine zipper protein is a novel scaffolding protein in the Galpha13 signaling pathway.
Biochemistry - 1 Nov 2005
Kashef Kimia, Lee Clement M, Ha Ji Hee, Reddy E Premkumar, Dhanasekaran Danny N
Abstract excerpt
Scaffolding proteins play a critical role in conferring specificity and fidelity to signaling pathways. The JNK-interacting leucine zipper protein (JLP) has been identified as a scaffolding protein involved in linking components of the JNK signaling module. Galpha(12) and Galpha(13), the alpha-subunits of heterotrimeric G proteins G12 and G13, respectively, stimulate the JNK module in diverse cell types. Here, we...
Topics
- Animals
- COS Cells
- Cell Line
- Chlorocebus aethiops
- DNA-Binding Proteins
- GTP-Binding Protein alpha Subunits, G12-G13
- JNK Mitogen-Activated Protein Kinases
- Leucine Zippers
- Mutation
- Protein Binding
- Signal Transduction