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Article

Oncogenic mutant of Galpha12 stimulates cell proliferation through cycloxygenase-2 signaling pathway.

Oncogene - 2 Dec 1999

Dermott J M, Reddy M R, Onesime D, Reddy E P, Dhanasekaran N

Abstract excerpt

Expression of the GTPase-deficient, activated mutant alpha-subunit of the heterotrimeric G protein G12 (Galpha12QL) leads to the neoplastic transformation of fibroblast cell lines. The mitogenic pathway regulated by Galpha12QL includes an extensive signaling network involving several small GTPases and various kinases. In addition, Galpha12QL has been shown to potentiate the serum-induced phospholipase-A2 activity...

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Source

Identifiers

PMID: 10602471
DOI: 10.1038/sj.onc.1203345

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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