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Article

G alpha 13-mediated transformation and apoptosis are permissively dependent on basal ERK activity.

American journal of physiology. Cell physiology - 1 Oct 2003

Adarichev Vyacheslav A, Vaiskunaite Rita, Niu Jiaxin, Balyasnikova Irina V, Voyno-Yasenetskaya Tatyana A

Abstract excerpt

We previously reported that the alpha-subunit of heterotrimeric G13 protein induces either mitogenesis and neoplastic transformation or apoptosis in a cell-dependent manner. Here, we analyzed which signaling pathways are required for G alpha 13-induced mitogenesis or apoptosis using a novel mutant of G alpha 13. We have identified that in human cell line LoVo, the mutation encoding substitution of Arg260 to stop...

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Identifiers

PMID: 12736137
DOI: 10.1152/ajpcell.00115.2003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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