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Article

Transactivation of platelet-derived growth factor receptor alpha by the GTPase-deficient activated mutant of Galpha12.

Molecular and cellular biology - 1 Jan 2006

Kumar Rashmi N, Ha Ji Hee, Radhakrishnan Rangasudhagar, Dhanasekaran Danny N

Abstract excerpt

The GTPase-deficient, activated mutant of Galpha12 (Galpha12Q229L, or Galpha12QL) induces neoplastic growth and oncogenic transformation of NIH 3T3 cells. Using microarray analysis, we have previously identified a role for platelet-derived growth factor receptor alpha (PDGFRalpha) in Galpha12-mediated cell growth (R. N. Kumar et al., Cell Biochem. Biophys. 41:63-73, 2004). In the present study, we report that...

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Identifiers

PMID: 16354679
DOI: 10.1128/MCB.26.1.50-62.2006
PMCID: PMC1317640

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Source receipt: pubmed, retrieved 7 Sept 2026.

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