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Article

Mutant alpha-subunit of the G protein G12 activates proliferation and inhibits differentiation of 3T3-F442A preadipocytes.

Endocrinology - 1 Jun 1998

Denis-Henriot D, de Mazancourt P, Morot M, Giudicelli Y

Abstract excerpt

We studied the G protein alpha-subunit Galpha12 in various tissues and cell lines. Significant amounts of Galpha12 were detected by immunoblots in liver, chromaffin cells, RINm5F cells, 3T3-F442A cells, and preadipocytes, but not in adipocytes, sperm, kidney, NB2A cells, or brain. To study the ro...

Topics

Adipocytes
Animals
Calcium-Calmodulin-Dependent Protein Kinases
Cell Differentiation
Cell Division
Cell Line
GTP-Binding Proteins
Mutation
Protein Serine-Threonine Kinases
Proto-Oncogene Proteins c-raf
Stem Cells

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Identifiers

PMID: 9607799
DOI: 10.1210/endo.139.6.6038

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9607799-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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