Article
Activated mutant of G alpha 13 induces Egr-1, c-fos, and transformation in NIH 3T3 cells.
Oncogene - 1 Aug 1994
Vara Prasad M V, Shore S K, Dhanasekaran N
Abstract excerpt
Expression of the constitutively activated mutant alpha-subunit of the heterotrimeric G protein G alpha 13 (alpha 13Q226L) leads to the transformation of NIH-3T3 cells. An analysis of the mitogenic pathway mediated by alpha 13Q226L indicated that the expression of the primary response genes, earl...
Topics
- 3T3 Cells
- Animals
- Base Sequence
- Cell Transformation, Neoplastic
- DNA-Binding Proteins
- Early Growth Response Protein 1
- GTP-Binding Proteins
- Gene Expression Regulation
- Genes, fos
- Immediate-Early Proteins
- Mice
- Molecular Sequence Data
- Mutation
- Protein Kinase C
- Transcription Factors