Article
Galpha13 mediates activation of the cytosolic phospholipase A2alpha through fine regulation of ERK phosphorylation.
Cellular signalling - 1 Dec 2006
Mariggiò Stefania, Bavec Aljosa, Natale Elena, Zizza Pasquale, Salmona Mario, Corda Daniela, Di Girolamo Maria
Abstract excerpt
Heterotrimeric GTP-binding (G) proteins transduce hormone-induced signals to their effector enzymes, which include several phospholipases. In particular, the G(o)/G(i) and G(q) protein families have been shown to couple signaling to phospholipase A(2) (PLA(2)), phospholipase C, and phospholipase D, while the G(12)/G(13) family has been linked to the activation of small GTPases of the Rho family, and hence, to...
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