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Article

Role of Lbc RhoGEF in Galpha12/13-induced signals to Rho GTPase.

Cellular signalling - 1 Feb 2004

Dutt Parmesh, Nguyen Nhan, Toksoz Deniz

Abstract excerpt

Heterotrimeric Galpha12/13 signals induce cellular responses such as serum response element (SRE)-mediated gene transcription via Rho GTPase. Guanine nucleotide exchange factors (GEFs) are strong candidates for linking Galpha signals to Rho. For example, p115 RhoGEF transduces Galpha13 signals to Rho and inhibits Galpha12/13 signals via the RhoGEF LH domain which links to Galpha subunits. Here, we have evaluated...

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Share to A Kinase Anchor Proteins
Share to Adaptor Proteins, Signal Transducing
Share to GTP-Binding Protein alpha Subunits, G12-G13

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 14636890
DOI: 10.1016/s0898-6568(03)00132-3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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