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Article

Hyperactive transposase mutants of the Sleeping Beauty transposon.

Molecular therapy : the journal of the American Society of Gene Therapy - 1 Dec 2005

Baus James, Liu Li, Heggestad Arnold D, Sanz Sonia, Fletcher Bradley S

Abstract excerpt

Transposable elements have enormous potential to overcome one of the major hurdles in nonviral gene delivery, namely the lack of long-term gene expression. The Sleeping Beauty (SB) transposon is a promising vector system for nonviral gene therapy as it has the highest transposition activity of all known DNA transposons within mammalian cells. In an effort to generate a more efficient delivery vehicle, we...

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Identifiers

PMID: 16150650
DOI: 10.1016/j.ymthe.2005.06.484

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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