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Article

Structural basis for stable DNA complex formation by the caspase-activated DNase.

The Journal of biological chemistry - 16 Dec 2005

Reh Stefanie, Korn Christian, Gimadutdinow Oleg, Meiss Gregor

Abstract excerpt

We describe a structural model for DNA binding by the caspase-activated DNase (CAD). Results of a mutational analysis and computational modeling suggest that DNA is bound via a positively charged surface with two functionally distinct regions, one being the active site facing the DNA minor groove and the other comprising distal residues close to or directly from helix alpha4, which binds DNA in the major groove....

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Source

Identifiers

PMID: 16236713
DOI: 10.1074/jbc.M509133200

Genes

CAD

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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